Model for capping of membrane receptors based on boundary surface effects

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Model for capping of membrane receptors based on boundary surface effects.

Crosslinking of membrane surface receptors may lead to their segregation into patches and then into a single large aggregate at one pole of the cell. This process is called capping. Here, a novel explanation of such a process is presented in which the membrane is viewed as a supersaturated solution of receptors in the lipid bilayer and the adjacent two aqueous layers. Without a crosslinking age...

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Possible role of nucleus-membrane interaction in capping of surface membrane receptors.

Interaction of multivalent ligands and cell surface receptors can induce redistribution of these receptors to form patches and caps. In this study, we have investigated the role of nucleus-membrane interaction in the capping of membrane components. Mouse L cells and leukemia EL4 cells were enucleated with the aid of cytochalasin B, yielding cytoplasts and karyoplasts. Capping of surface recepto...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 1978

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.75.3.1357